The World's First Totally Implantable, Programmable Micro Infusion Pump for Mouse Animal Model Infusion. This implantable infusion pump uses a patented, microprocessor controlled peristalsis mechanism for accurate controlled flow. It is the only implantable and programmable pump for mice. iPRECIO can infuse fluids continuously at accurate low flow rate via software programming and it can be refilled via a percutaneously accessible port.
The pump can be completely implanted in small laboratory animals subcutaneously. Thus, the animal moves freely without any restrain (i.e. tethering) during drug infusion. Additionally, infection risk is reduced, and the animal is likely to be significantly less stressed than in a tethered infusion model.
You can replenish any medical fluid in the pump via percutaneous access to the pump refill septum and reservoir after implantation of the pump. So, long-term drug infusion can continue until the installed battery life has run out. The reservoir is elastic and configured in such geometry as to allow gentle palpation to confirm an approximate level of fluid in the reservoir.
Using the easy to use state of the art iPRECIO® software, header information along with infusion profile details are entered and ultimately downloaded to the pump's memory. Start Time, End Time, Flow-rate (0.0µl/hour to 10.0µl/hour), and infusion profiles may be programmed. These profiles include sustained release, modified release, chrono release and pulsatile release. A total of 15 steps with repeat function allows both complex and simple infusion profiles to be programmed.
A recovery period may also be programmed using the Keep Vein Open Function (KVO) where saline is initially filled in the reservoir. A dead volume flushing function also ensures that the test article (TA) hits the animal at the programmed time point.
The programmable feature will make iPRECIO® pumps indispensable for applications where accurate flow infusion, recovery/washout periods, constant/variable dose or complex circadian infusion studies are necessary.
Wireless programming allows all pumps to be conveniently detected, assigned, programmed and monitored via our IMS-310R iPRECIO Management system. Once completely programmed wirelessly, the iPRECIO SMP-310R Pumps will independently infuse as programmed until completed or aborted without any further communications with the IMS-310R.
In ideal conditions* with a small number pumps, SMP-310R Micro Infusion Pump allows in-vivo re-programming for maximum flexibility. If no effect is detected, pump may be re-programmed to infuse at a higher flow rate. A higher concentration drug/TA may also be used. Communications Availability (Comms Avail) of SMP-310R may be programmed to maximize battery life or maximum responsiveness. Options are provided in Infusion Profile (Group ID) settings.
The technology driving the infusion is a patented "Rotary Finger" method. This method is a unique form of peristalsis. The precise "micro-stick" pushes a rubber tube in the pump in a uniform and sequential manner. The accuracy of iPRECIO is +/-5%.
|Dimensions||24.8 x 15.0 x 7.4 mm partially 8.2 (not including outer catheter )|
|Accuracy||±5% (under 0 - 80 cmH2O pressure)|
|Battery||Continuous driving life : FR 0.1µL/hr：67 days, FR 8.0µL/hr：10 days, FR 10µL/hr：8 days for No-Comms mode Setting (none). FR 0.1ul/hr : 6.5 days , 8ul/hr : 5 days, 10ul/hr : 5 days for Comms Avail of 1 minute.|
|Type of Usage||Disposable|
|Infusion Method||Rotary Finger Method (patented peristalsis)|
|Reservoir||130μL Built-in Elastic Reservoir (Medical Grade SEBS)|
|Tubing||Medical Grade SEBS|